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Protection mechanisms have evolved that limit their mobilization. The clasd nature of these protecting mechanisms came to light with the discovery of RNA silencing pathways. In most species, the length distribution of piRNAs is relatively broad. In this review, we discuss the latest results from studies mainly performed in Drosophila melanogaster that have provided a better understanding of this major protecting pathway active against external and internal genomic invaders from unicellulars to human.

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In addition, Aub-bound piRNAs play an important role in anchoring the transcripts involved in scoth localization and germline development.

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